SSRI Activation Syndrome vs. Common Side Effects vs Bipolar Switch: According to a Psychiatrist

Started an SSRI and suddenly feel wired, edgy, or oddly restless? While most people expect “nausea” or “sleep changes,” psychiatrists also watch for a more specific early-treatment reaction called serotonin (SSRI) activation syndrome. Confusing it with routine side effects—or with a bipolar mood switch—can derail treatment. Let’s Discuss!